{"product_id":"cst-77399s","title":"CST,  77399S, CD39\/NTPDase 1 (E2X6B) Rabbit Monoclonal Antibody (Alexa Fluor® 647 Conjugate)","description":"Monoclonal Antibody for studying CD39 mouse. Validated for Immunohistochemistry (Paraffin). Highly specific and rigorously validated in-house, CD39\/NTPDase 1 (E2X6B) Rabbit Monoclonal Antibody (Alexa Fluor\u003csup\u003e®\u003c\/sup\u003e 647 Conjugate) (CST #77399) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nImmunohistochemistry (Paraffin): 1:100 - 1:400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg\/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCD39\/NTPDase 1 (E2X6B) Rabbit Monoclonal Antibody (Alexa Fluor\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys307 of mouse NTPDase 1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nEctonucleoside triphosphate diphosphohydrolase 1 (NTPDase 1, also known as CD39) is a multi-pass membrane ectoenzyme that metabolizes adenosine-5'-triphosphate (ATP) to regulate purinergic signaling. Purinergic signaling by extracellular ATP and its metabolites regulate many biological processes, including vascular tone, digestion, neuronal function, and inflammation in both normal and diseased states (1). NTPDase 1 is expressed in endothelial cells in the vasculature to regulate local platelet purinergic signaling via metabolism of ATP to adenosine (2). Accordingly, NTPDase 1 regulates platelet activation aggregation and contributes to the antithrombotic properties of endothelial cells (3). ATP and its metabolites also finely modulate the activity of T cells and macrophages (4,5). Immunomodulation is regulated, in part, by the availability of extracellular ATP and adenosine, suggesting that NTPDase 1 (CD39) may play an immunosuppressive role in the tumor microenvironment.\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n2610206B08Rik; AA408691; Cd39; CD39 antigen; E130009M23Rik; Ecto-apyrase; Ecto-ATP diphosphohydrolase 1; Ecto-ATPase 1; Ecto-ATPDase 1; ectoa; ectoapyrase; Ectonucleoside triphosphate diphosphohydrolase 1; ENTP1; Entpd1; Lymphoid cell activation antigen; NTPDa; NTPDase 1; NTPDase-1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800528769193,"sku":"77399S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-77399s","provider":"Iright","version":"1.0","type":"link"}