{"product_id":"cst-7825s","title":"CST,  7825S, PathScan® Total VEGFR-2 Sandwich ELISA Antibody Pair","description":"ELISA Antibody Pair for studying VEGFR2 in the research area.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nCapture and detection antibodies are stored at 4°C. HRP-linked secondary reagent is stored at -20°C.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: ELISA+\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nFor Antibody Pair specificity and sensitivity, please refer to the corresponding PathScan\nSpecies Reactivity: Human\n\u003cb\u003eBackground\u003c\/b\u003e\nVascular endothelial growth factor receptor 2 (VEGFR2, KDR, Flk-1) is a major receptor for VEGF-induced signaling in endothelial cells. Upon ligand binding, VEGFR2 undergoes autophosphorylation and becomes activated (1). Major autophosphorylation sites of VEGFR2 are located in the kinase insert domain (Tyr951\/996) and in the tyrosine kinase catalytic domain (Tyr1054\/1059) (2). Activation of the receptor leads to rapid recruitment of adaptor proteins, including Shc, GRB2, PI3 kinase, NCK, and the protein tyrosine phosphatases SHP-1 and SHP-2 (3). Phosphorylation at Tyr1212 provides a docking site for GRB2 binding and phospho-Tyr1175 binds the p85 subunit of PI3 kinase and PLCγ, as well as Shb (1,4,5). Signaling from VEGFR2 is necessary for the execution of VEGF-stimulated proliferation, chemotaxis and sprouting, as well as survival of cultured endothelial cells and angiogenesis (6-8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nKDR; VEGF Receptor; vegfr; VEGFR-2 elisa; vegfr2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H","brand":"CST","offers":[{"title":"Default Title","offer_id":46800664002729,"sku":"7825S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-7825s","provider":"Iright","version":"1.0","type":"link"}