{"product_id":"cst-78409t","title":"CST,  78409T, METTL5 (F4E9V) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying METTL5. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, METTL5 (F4E9V) Rabbit Monoclonal Antibody (CST #78409) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMETTL5 (F4E9V) Rabbit Monoclonal Antibody recognizes endogenous levels of total METTL5 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu13 of human METTL5 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMethyltransferase-like protein 5 (METTL5) forms a stable complex with TRMT112 in order to catalyze N6-methyladenosine on the 18S rRNA at position 1832 (1). METTL5 can affect the global translation rate, pluripotency, differentiation, and neural development (2-4). High expression of METTL5 has been described in lung adenocarcinoma where it contributes to epithelial-mesenchymal transition (5,6). In pancreatic cancer, METTL5 promotes Myc translation to drive progression (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFLJ10459; HSPC133; methyltransferase like 5; Methyltransferase-like protein 5; METL5; METTL5; MRT72; rRNA N6-adenosine-methyltransferase METTL5\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 26\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799906013353,"sku":"78409T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-78409t","provider":"Iright","version":"1.0","type":"link"}