{"product_id":"cst-78524s","title":"CST,  78524S, CTHRC1 (E6W2E) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CTHRC1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, CTHRC1 (E6W2E) Rabbit Monoclonal Antibody (CST #78524) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCTHRC1 (E6W2E) Rabbit Monoclonal Antibody recognizes endogenous levels of total CTHRC1 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala226 of human CTHRC1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCollagen triple helix repeat containing-1 (CTHRC1) is a secreted glycoprotein involved in wound repair, vascular and bone remodeling, matrix deposition, and migration. CTHRC1 is overexpressed in multiple human cancers, and its expression is associated with increased migration and metastasis, as well as decreased survival (1-3). CTHRC1 expression is regulated through TGF-β\/Smad3 signaling, and its effects on migration and invasion are mediated by several signaling pathways, including TGF-β, Wnt, integrin β\/FAK, Src\/FAK, MEK\/ERK, PI3K\/AKT\/ERK, HIF-1α, and PKC-δ\/ERK (3). CTHRC1 protein is elevated in the peripheral blood of Rheumatoid arthritis (RA) patients, and CTHRC1 is thought to be a driver of RA progression (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\ncollagen triple helix repeat containing 1; Collagen triple helix repeat-containing protein 1; CTHR1; CTHRC1; Q96CG8\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 29\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799906177193,"sku":"78524S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-78524s","provider":"Iright","version":"1.0","type":"link"}