{"product_id":"cst-79004s","title":"CST,  79004S, ISG20 (E6A2Z) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ISG20. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, ISG20 (E6A2Z) Rabbit Monoclonal Antibody (CST #79004) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nISG20 (E6A2Z) Rabbit Monoclonal Antibody recognizes endogenous levels of total ISG20 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human ISG20 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nInterferon-stimulated 20 kDa protein (ISG20) is an exoribonuclease that functions as part of the host innate immune response to RNA-based viruses. Indeed, expression of ISG20 can be induced by type-I and type-II interferons following cellular exposure to RNA-based viruses (1). Mechanistically, ISG20 localizes to the nucleolus and is believed to inhibit the replication of RNA-based viruses, in part, by employing 3'-5' exonuclease activity toward viral RNAs (2-5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCD25; Estrogen-regulated transcript 45 protein; HEM45; interferon stimulated exonuclease gene 20; interferon stimulated exonuclease gene 20kDa; Interferon-stimulated gene 20 kDa protein; ISG20; Promyelocytic leukemia nuclear body-associated protein ISG20\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 20\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799907750057,"sku":"79004S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-79004s","provider":"Iright","version":"1.0","type":"link"}