{"product_id":"cst-79057t","title":"CST,  79057T, APEX2 (F7N2G) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying APEX2. Validated for WB,WB,IP,IF. Available in 2 sizes. Highly specific and rigorously validated in-house, APEX2 (F7N2G) Rabbit Monoclonal Antibody (CST #79057) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\nImmunoprecipitation: 1:100\nImmunofluorescence (Immunocytochemistry): 1:800\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nAPEX2 (F7N2G) Rabbit Monoclonal Antibody recognizes endogenous levels of total APEX2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu393 of human APEX2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nDNA-(apurinic or apyrimidinic site) endonuclease 2 (APEX2\/APE2) is an endodeoxyribonuclease that functions in the DNA base excision repair (BER) pathway to repair DNA lesions induced by oxidative and alkylating agents. APEX2 acts in ATR-dependent DNA damage checkpoint activation in response to oxidative stress (1). The gene is synthetically lethal with and genes, which are required for homologous recombination (HR) repair of double-strand DNA breaks. This is due to the ability of APEX2 to reverse single-strand DNA breaks with 3' end blocks. Because BRCA-deficient cancer cells are sensitive to 3' blocks, APEX2 is a potential therapeutic target for HR-deficient cancers (2,3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAP endonuclease 2; AP endonuclease XTH2; APE2; APEX nuclease (apurinic\/apyrimidinic endonuclease) 2; APEX nuclease 2; APEX nuclease-like 2; APEX2; APEXL2; Apurinic-apyrimidinic endonuclease 2; apurinic\/apyrimidinic endodeoxyribonuclease 2; apurinic\/apyrimidinic endonuclease-like 2; DNA-(apurinic or apyrimidinic site) endonuclease 2; DNA-(apurinic or apyrimidinic site) lyase 2; XTH2; ZGRF2; zinc finger, GRF-type containing 2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 62\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799908110505,"sku":"79057T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-79057t","provider":"Iright","version":"1.0","type":"link"}