{"product_id":"cst-79104t","title":"CST,  79104T, ELF4 (F8H6X) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ELF4. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, ELF4 (F8H6X) Rabbit Monoclonal Antibody (CST #79104) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nELF4 (F8H6X) Rabbit Monoclonal Antibody recognizes endogenous levels of total ELF4 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human ELF4 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nETS-related transcription factor Elf-4 (ELF4), also known as myeloid Elf-1-like factor (MEF), is a member of the ETS-family of transcription factors, all containing a well-conserved ETS DNA-binding domain that recognizes a core consensus sequence defined as 5-'GGAA' (1,2). In addition to being a transcriptional activator, ELF4 also plays many roles within the immune system, such as regulating natural killer (NK) cell development and perforin expression, CD8 T cell proliferation, anti-viral immunity through type I interferon, and TH17 cell differentiation (1-6). Lack of in humans has been associated with deficiency in ELF4, X-linked (DEX), a monogenic autoinflammatory disease (mAID) (5,6). In mouse models, KO macrophages failed to sustain the transcription of key anti-inflammatory genes and instead upregulated proinflammatory genes (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nE74 like ETS transcription factor 4; E74-like factor 4; E74-like factor 4 (ets domain transcription factor); ELF4; ELFR; ETS-related transcription factor Elf-4; MEF; Myeloid Elf-1-like factor\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 75-100\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799908274345,"sku":"79104T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-79104t","provider":"Iright","version":"1.0","type":"link"}