{"product_id":"cst-7918v2","title":"CST,  7918V2, PathScan® Total Cyclin D1 Sandwich ELISA Kit","description":"ELISA Kit for studying Cyclin D1 in the research area.\n\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: ELISA+\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPathScan\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eBackground\u003c\/b\u003e\nActivity of the cyclin-dependent kinases CDK4 and CDK6 is regulated by T-loop phosphorylation, by the abundance of their cyclin partners (the D-type cyclins), and by association with CDK inhibitors of the Cip\/Kip or INK family of proteins (1). The inactive ternary complex of cyclin D\/CDK4 and p27 Kip1 requires extracellular mitogenic stimuli for the release and degradation of p27 concomitant with a rise in cyclin D levels to affect progression through the restriction point and Rb-dependent entry into S-phase (2). The active complex of cyclin D\/CDK4 targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1\/S-phase gene expression (3). Levels of cyclin D protein drop upon withdrawal of growth factors through downregulation of protein expression and phosphorylation-dependent degradation (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nB-cell CLL\/lymphoma 1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; BCL1; CCND1; CycD1; cyclin D1; D11S287E; G1\/S-specific cyclin D1; G1\/S-specific cyclin-D1; PRAD1; PRAD1 oncogene; U21B31\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk","brand":"CST","offers":[{"title":"Default Title","offer_id":46800667148457,"sku":"7918V2","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-7918v2","provider":"Iright","version":"1.0","type":"link"}