{"product_id":"cst-79606t","title":"CST,  79606T, PCGF3 (F3X9C) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PCGF3. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PCGF3 (F3X9C) Rabbit Monoclonal Antibody (CST #79606) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPCGF3 (F3X9C) Rabbit Monoclonal Antibody recognizes endogenous levels of total PCGF3 protein. This antibody does not cross-react with PCGF5 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro64 of human PCGF3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPolycomb group RING finger homologs (PCGF1-6) are essential proteins for the assembly of the polycomb repressive complex 1 (PRC1) group of complexes. RING1A\/B and a unique PCGF protein make up the catalytic core of PRC1 to ubiquitinate histone H2A. Differences in binding specificities give PRC1 complexes unique functions depending on which PCGF is included (1-3). PCGF3 is closely related to PCGF5 and recruits PRC1 and PRC2 in response to Xist expression (4). PCGF3\/5 can act as transcriptional activators in embryonic stem cells, where they interact with Tex10, a pluripotency and super-enhancer regulator (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDKFZp686D20235; DONG1; FLJ36550; FLJ43813; MGC129615; MGC40413; PCGF3; polycomb group ring finger 3; Polycomb group RING finger protein 3; ring finger protein 3; RING finger protein 3A; RNF3; RNF3A\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 28\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799910633641,"sku":"79606T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-79606t","provider":"Iright","version":"1.0","type":"link"}