{"product_id":"cst-79938s","title":"CST,  79938S, Dynamin 3 (E5R5E) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying DYN3. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Dynamin 3 (E5R5E) Rabbit Monoclonal Antibody (CST #79938) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nDynamin 3 (E5R5E) Rabbit Monoclonal Antibody recognizes endogenous levels of total dynamin 3 protein. This antibody does not cross-react with other dynamin proteins.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser783 of human dynamin 3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nDynamin is a family of large GTPases that has been implicated in the formation of vesicles of both endocytotic and secretory processes (1). Dynamin plays an important role in the internalization of cell surface receptors, a process that attenuates the response to extracellular signals. There are three isoforms of dynamin. Dynamin 1 and 3 expression is enriched in the brain, while dynamin 2 expression is ubiquitous. All three isoforms mediate membrane fission during clathrin-mediated endocytosis. Dynamin 2 is also suggested to be involved in non-clathrin-mediated endocytosis and cytoskeletal interactions (2-4). Dynamin 3 is suggested to regulate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor recycling through its interaction with the postsynaptic density scaffolding proteins Homer and Shank (5-7). In addition to the role they play in neurotransmission, dynamin family members are considered therapeutic targets in cancer. Dysregulation of endocytosis in cancer leads to dysfunction in cell signaling, survival, and proliferation. Dynamin 1 and 2 have been shown to promote tumorigenesis, while dynamin 3 is a suggested tumor suppressor (8-12).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDNM3; DYN3; Dyna III; dynamin 3; dynamin family member; Dynamin-3; Dynamin, testicular; KIAA0820; MGC70433; T-dynamin\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 100\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799912304809,"sku":"79938S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-79938s","provider":"Iright","version":"1.0","type":"link"}