{"product_id":"cst-79990s","title":"CST,  79990S, ROD1 (E6B2J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ROD1. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, ROD1 (E6B2J) Rabbit Monoclonal Antibody (CST #79990) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nROD1 (E6B2J) Rabbit Monoclonal Antibody recognizes endogenous levels of total ROD1 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly422 of human ROD1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nROD1, also known as PTBP3, is a member of the polypyrimidine tract-binding (PTB) protein family and a critical RNA-binding factor (1). Characterization of the mRNA and protein isoforms of ROD1 has revealed that alternative splicing surrounding the 5′ end of the gene leads to the generation of eight mRNA and three major protein isoforms. Specifically, alternative translation by re-initiation and leaky scanning through downstream start codons leads to the generation of up to three protein isoforms with varying domains and RNA-binding properties (2). ROD1 has been shown to play functional roles in RNA splicing, translational activation, and mRNA stability and is deregulated in numerous cancers, including breast, gastric, and colorectal cancer (3-6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDKFZp781I1117; fission yeast differentiation regulator; polypyrimidine tract binding protein 3; Polypyrimidine tract-binding protein 3; PTBP3; Regulator of differentiation 1; ROD1; ROD1 regulator of differentiation 1; ROD1 regulator of differentiation 1 (S. pombe)\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 48, 58\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799912698025,"sku":"79990S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-79990s","provider":"Iright","version":"1.0","type":"link"}