{"product_id":"cst-80577s","title":"CST,  80577S, Talazoparib","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nTalazoparib is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.31 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nTalazoparib (BMN 673) is a potent, selective PARP inhibitor with an IC value for PARP1 of 0.57 nM. It can inhibit both PARP1 and PARP2, but not PARG. Talazoparib selectively targets tumor cells with , , and gene mutations. It is effective in inducing antitumor activity in xenografted tumors from mice (1).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n(8S,9R)-5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3Hpyrido[ 4,3,2-de]phthalazin-3-one; BMN673","brand":"CST","offers":[{"title":"Default Title","offer_id":46800698638505,"sku":"80577S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-80577s","provider":"Iright","version":"1.0","type":"link"}