{"product_id":"cst-80817t","title":"CST,  80817T, MS4A7 (E3E1A) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MS4A7. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MS4A7 (E3E1A) Rabbit Monoclonal Antibody (CST #80817) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMS4A7 (E3E1A) Rabbit Monoclonal Antibody recognizes endogenous levels of total MS4A7 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MS4A7 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMembrane-spanning 4-domains subfamily A member 7 (MS4A7) is a member of a class of genes encoding four transmembrane-spanning proteins (1,2). MS4A7 is involved in signal transduction as a component of a multimeric receptor complex. Expression of the gene is primarily restricted to microglia in the brain (3). Interestingly, MS4A7, as well as other members of the gene cluster, is genetically linked to late-onset Alzheimer's disease, suggesting that MS4A-dependent microglia might contribute to neurodegenerative disease progression (4).    Â\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n4SPAN2; CD20 antigen-like 4; CD20\/FC-epsilon-RI-beta family member 4; CD20L4; CFFM4; Four-span transmembrane protein 2; high affinity immunoglobulin epsilon receptor beta subunit; membrane spanning 4-domains A7; Membrane-spanning 4-domains subfamily A member 7; membrane-spanning 4-domains, subfamily A, member 7; MGC22368; MS4A7; MS4A8\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 20\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799919153321,"sku":"80817T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-80817t","provider":"Iright","version":"1.0","type":"link"}