{"product_id":"cst-8132s","title":"CST,  8132S, 17-AAG","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\n17-AAG is supplied as a lyophilized powder. For a 1 mM stock, reconstitute the 500 μg in 853.7 μl DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 0.1-1 μM for 4-24 hours. Soluble in DMSO at 150 mg\/mL; soluble in ethanol at 5 mg\/mL. Maximum solubility in plain water estimated to be about 20-50 μM.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized or in solution at -20ºC, desiccated. Protect from light. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\n17-AAG is a semi-synthetic derivative of geldanamycin, demonstrating greater stability than its parent compound (1). It binds specifically to heat shock protein HSP90 in a manner similar to geldanamycin, but with weaker binding (1). Through specific binding with HSP90, 17-AAG has been shown to decrease levels of many proteins including androgen receptor (AR), HER2, and Akt, while increasing levels of HSP90 in prostate cancer cell lines (2). 17-AAG binds to a conserved pocket in the HSP90 family of chaperone proteins and this occupation causes the degradation of several signaling proteins (2).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n17-Allylaminogeldanamycin; 17-Allylaminogeldanamycin; 17aag; 17Allylamino geldanamycin; geldanamycin; HSP90; Tanespimycin","brand":"CST","offers":[{"title":"Default Title","offer_id":46800698867881,"sku":"8132S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-8132s","provider":"Iright","version":"1.0","type":"link"}