{"product_id":"cst-81458w2","title":"CST,  81458W2, 4-1BB\/CD137\/TNFRSF9 (D2Z4Y) Rabbit Monoclonal Antibody (SignalFlex™ mFluor™ Violet 510 Conjugate)","description":"Monoclonal Antibody for studying TNFRSF9. Highly specific and rigorously validated in-house, 4-1BB\/CD137\/TNFRSF9 (D2Z4Y) Rabbit Monoclonal Antibody (SignalFlex\u003csup\u003e™\u003c\/sup\u003e mFluor\u003csup\u003e™\u003c\/sup\u003e Violet 510 Conjugate) (CST #81458) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nSignalFlex™ conjugates are produced using highly validated Cell Signaling Technology ® primary antibodies and conjugation methods that have been rigorously tested, ensuring high-quality conjugates and lot-to-lot consistency. These conjugates are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity. However, they are not tested on specific assays. Optimal dilutions\/concentrations should be determined by the end user. When performing flow cytometry, we recommend using an isotype control conjugate at the same concentration as the antibody conjugate.\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg\/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\n4-1BB\/CD137\/TNFRSF9 (D2Z4Y) Rabbit mAb (SignalFlex™ mFluor™ Violet 510 Conjugate) recognizes endogenous levels of total 4-1BB\/CD137\/TNFRSF9 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a recombinant protein specific to the extracellular domain of human 4-1BB\/CD137\/TNFRSF9 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nTNFRSF9 is a member of the tumor necrosis factor receptor superfamily (1,2). It is also called 4-1BB or CD137 (1, 2). 4-1BB\/CD137\/TNFRSF9 is expressed in activated CD4+ and CD8+ T cells, natural killer cells and dendritic cells (2-5). The ligand 4-1BBL\/CD137L\/TNFSF9 on antigen presenting cells binds to 4-1BB\/CD137\/TNFRSF9 and costimulates the activation of T cells (5). The binding of agonistic antibodies to 4-1BB\/CD137\/TNFRSF9 also leads to costimulation for T cell activation (5). Studies have shown the effectiveness of targeting 4-1BB\/CD137\/TNFRSF9 by its agonistic antibodies in cancer immunotherapy (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n4-1BB; 4-1BB ligand receptor; CD137; CD137 antigen; CDw137; homolog of mouse 4-1BB; ILA; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; MGC2172; receptor protein 4-1BB; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; TNFRSF9; TNR9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800537419945,"sku":"81458W2","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-81458w2","provider":"Iright","version":"1.0","type":"link"}