{"product_id":"cst-81569s","title":"CST,  81569S, MCT4\/SLC16A3 (F2K6A) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MCT4. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MCT4\/SLC16A3 (F2K6A) Rabbit Monoclonal Antibody (CST #81569) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMCT4\/SLC16A3 (F2K6A) Rabbit Monoclonal Antibody recognizes endogenous levels of total MCT4\/SLC16A3 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human MCT4\/SLC16A3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMCT4, also known as MOT4 or SLC16A3, is a multi-pass transmembrane monocarboxylate transporter (MCT) protein encoded by the gene (1,2). MCT4 is reported to be expressed in white (glycolytic) muscle cells (3,4), astrocytes (5), activated macrophages (6), and cancer cells (2). The primary role of MCT4 is lactate exportation, which is adapted to the release of lactate from glycolytic cells (8,9). In the tumor microenvironment, MCT4 mediated lactate secretion promotes M2 macrophage polarization and suppresses T cell function (10). MCT4 inhibition increases the efficacy of immune checkpoint blockade and is a potential target to reverse tumor resistance to immunotherapy (11,12).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nMCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4; MGC138472; MGC138474; Monocarboxylate transporter 3; Monocarboxylate transporter 4; MOT4; SLC16A3; solute carrier family 16 (monocarboxylate transporter), member 3; solute carrier family 16 (monocarboxylic acid transporters), member 3; Solute carrier family 16 member 3; solute carrier family 16, member 3; solute carrier family 16, member 3 (monocarboxylic acid transporter 4)\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 40\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799925149865,"sku":"81569S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-81569s","provider":"Iright","version":"1.0","type":"link"}