{"product_id":"cst-81692t","title":"CST,  81692T, MUC4 beta (D4W9X) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MUC4 (beta chain). Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, MUC4 beta (D4W9X) Rabbit Monoclonal Antibody (CST #81692) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:250 - 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMUC4 beta (D4W9X) Rabbit Monoclonal Antibody recognizes endogenous levels of total MUC4 protein (β subunit).\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human MUC4 protein (β subunit).\n\u003cb\u003eBackground\u003c\/b\u003e\nMUC4 is a membrane-bound mucin family member (1,2). It is a heterodimer of extracellular α subunits associated with a trans-membrane β subunit. There are 3 epidermal growth factor (EGF)-like domains in the extracellular region of the β subunit. These EGF-like domains can directly interact with ErbB2 to activate the downstream signaling pathways. MUC4 is expressed in the epithelial tissues of lung and gastrointestinal organs during development as well as in adult stage. It exerts a protective effect to these tissues against potential damage (3). Overexpression of MUC4 has been found in multiple types of cancers to promote cancer growth, survival, and metastasis (4-6). MUC4 has been proposed as a promising prognostic marker for cancer evaluation.\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAscites sialoglycoprotein; Ascites sialoglycoprotein 1; Ascites sialoglycoprotein 2; ASGP; ASGP-1; ASGP-2; HSA276359; MUC-4; MUC4; mucin 4, cell surface associated; mucin 4, tracheobronchial; Mucin-4; Mucin-4 alpha chain; Mucin-4 beta chain; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 100-170\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799926067369,"sku":"81692T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-81692t","provider":"Iright","version":"1.0","type":"link"}