{"product_id":"cst-81781s","title":"CST,  81781S, Mouse IL-5 Recombinant Protein","description":"Growth Factors and Cytokines for studying IL5 mouse in the research area.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nMouse IL-5 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg\/ml which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles if storing reconstituted material at -20ºC to -80ºC.\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nRecombinant mouse IL-5 was expressed in and is supplied in a lyophilized form.\n\u003cb\u003eBackground\u003c\/b\u003e\nIL-5 is a pleiotropic cytokine that is predominantly produced by Th2 T cells but can also be expressed by activated eosinophils, mast cells, NK cells, and iNKT cells (1-4). Both human and mouse IL-5 are glycosylated disulfide-linked homodimers (1). The IL-5 receptor is a heterodimer that consists of a high affinity IL-5 binding α chain and the common β chain, which is shared by GM-CSF and IL-3 receptors, for signal transduction (1,2). Soluble IL-5Rα binds with high affinity to IL-5, thereby inhibiting IL-5 activity (1). IL-5-mediated signaling can activate the Erk1\/2, Jak2, and Stat5 signaling pathways (1,2). In mice, IL-5 is important for the differentiation of antibody-secreting cells from activated B cells (2). IL-5 induces eosinophil activation, proliferation, and differentiation in both mice and humans (2,3).","brand":"CST","offers":[{"title":"Default Title","offer_id":46800717152425,"sku":"81781S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-81781s","provider":"Iright","version":"1.0","type":"link"}