{"product_id":"cst-81862s","title":"CST,  81862S, BRIP1\/FANCJ (F4I9N) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying BRIP1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, BRIP1\/FANCJ (F4I9N) Rabbit Monoclonal Antibody (CST #81862) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nBRIP1\/FANCJ (F4I9N) Rabbit Monoclonal Antibody recognizes endogenous levels of total BRIP1\/FANCJ protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys1177 of human BRIP1\/FANCJ protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nBACH1, also known as BRIP1 and FANCJ, is a DNA helicase involved in repairing DNA cross-links and double-strand breaks (1-3). Interaction between phosphorylated BACH1 and BRCA1 is required for DNA damage-induced checkpoint signaling (3,4). Originally identified as a breast cancer susceptibility gene (1), the gene is mutated in Fanconi anemia (5), a recessive disorder characterized by multiple congenital abnormalities, progressive bone marrow failure, and high cancer risk\/predisposition. Research investigators have concluded that BACH1 interactions with BRCA1 and the presence of mutations in patients with early-onset breast cancer indicate that BACH1 may act as a tumor suppressor (6).BACH1 phosphorylation at Thr1133 is thought to be involved in regulating the replication checkpoint and is required for BACH1 interaction with TopBP1 (7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nATP-dependent RNA helicase BRIP1; BACH1; BRCA1 interacting protein C-terminal helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; BRCA1\/BRCA2-associated helicase 1; BRIP1; FANCJ; Fanconi anemia group J protein; FLJ90232; MGC126521; MGC126523; OF; Protein FACJ\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 145\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799928066217,"sku":"81862S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-81862s","provider":"Iright","version":"1.0","type":"link"}