{"product_id":"cst-8186s","title":"CST,  8186S, FoxA2\/HNF3 beta (D56D6) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying FOXA2. Validated for Western Blotting,Immunoprecipitation,Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, FoxA2\/HNF3 beta (D56D6) Rabbit Monoclonal Antibody (CST #8186) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\nImmunofluorescence (Immunocytochemistry): 1:400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 38775 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nFoxA2\/HNF3 beta (D56D6) Rabbit Monoclonal Antibody recognizes endogenous levels of total FoxA2\/HNF3β protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly138 of human FoxA2\/HNF3β protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nForkhead box protein A2 (FoxA2, also known as hepatocyte nuclear factor 3β or HNF3β) is a transcription factor that plays an important role in hepatocyte function (1). FoxA2\/HNF3β is required for the activation of hepatic gluconeogenic gene expression during fasting (1). Together with the PGC-1β coactivator, FoxA2\/HNF3β stimulates the expression of genes involved in fatty acid β-oxidation and, therefore, increases fatty acid metabolism (2). FoxA2\/HNF3β, along with PGC-1β, also activates the expression of microsomal triacylglycerol transfer protein (MTP) and promotes VLDL secretion (2). In addition to its roles in metabolic syndromes, FoxA2\/HNF3β is essential for development of the endoderm and midline structures in mouse embryos (3-5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nforkhead box A2; Forkhead box protein A2; FOXA2; hepatic nuclear factor-3-beta; Hepatocyte nuclear factor 3-beta; hepatocyte nuclear factor 3, beta; HNF-3-beta; HNF-3B; HNF3B; MGC19807; TCF-3B; TCF3B; Transcription factor 3B\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 50\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799927836841,"sku":"8186S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-8186s","provider":"Iright","version":"1.0","type":"link"}