{"product_id":"cst-81935t","title":"CST,  81935T, KCTD12 (D8V4J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying KCTD12. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, KCTD12 (D8V4J) Rabbit Monoclonal Antibody (CST #81935) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nKCTD12 (D8V4J) Rabbit Monoclonal Antibody recognizes endogenous levels of total KCTD12 protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro177 of human KCTD12 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPotassium channel tetramerization domain-containing protein 12 (KCTD12) belongs to the family of KCTD proteins, which also contains KCTD8, 12b, and 16. These proteins are auxiliary subunits of GABAB receptors (1). The principal subunit of the GABA receptor is formed by two GABA receptors, which bind to GABA ligands, couple to G proteins to inhibit adenylate cyclase production, and gate ion channels (e.g., the GIRK channels) (2). The auxiliary subunits contribute to receptor desensitization. KCTD12 produces fast desensitization by uncoupling the βγ subunits of the G protein from their effector channels (3). Research studies indicate that KCTD12 represents a biomarker with diagnostic and prognostic potential for gastrointestinal stromal tumors (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBTB\/POZ domain-containing protein KCTD12; C13orf2; FLJ33073; KCD12; KCTD12; KIAA1778; PFET1; Pfetin; potassium channel tetramerisation domain containing 12; potassium channel tetramerization domain containing 12; Predominantly fetal expressed T1 domain; testicular tissue protein Li 100\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 33\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799929082025,"sku":"81935T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-81935t","provider":"Iright","version":"1.0","type":"link"}