{"product_id":"cst-81944t","title":"CST,  81944T, Aldolase C (E7I4X) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Aldolase C. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, Aldolase C (E7I4X) Rabbit Monoclonal Antibody (CST #81944) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nAldolase C (E7I4X) Rabbit Monoclonal Antibody recognizes endogenous levels of total fructose bisphosphate aldolase C protein. This antibody does not cross-react with fructose bisphosphate aldolase A or fructose bisphosphate aldolase B proteins. This antibody detects a non-specific band of unknown origin at 75 kDa in mouse lung tissue extracts.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn90 of human aldolase C protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nAldolase (fructose bisphosphate aldolase), a glycolytic enzyme, catalyzes the conversion of fructose 1, 6-bisphosphate to 3-phosphoglyceraldehyde. This ubiquitous enzyme is present as three different isozymes: aldolase A, aldolase B, and aldolase C. Research studies suggest that aldolase A expression potentially differentiates between nonneoplastic liver diseases and hepatocarcinoma (1). Furthermore, investigators have shown that changes in aldolase B gene expression levels have been observed in certain patients with this primary tumor (2,3). Aldolase C is primarily expressed in the central nervous system (4). Studies have shown increased detection of serum aldolase C following traumatic brain injury (TBI) and mild TBI, showing potential for aldolase C as a biomarker for TBI (5,6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nALDC; ALDOC; aldolase 3; aldolase C, fructose-bisphosphate; aldolase, fructose-bisphosphate C; Brain-type aldolase; epididymis secretory sperm binding protein; fructoaldolase C; fructose-1,6-biphosphate triosephosphate lyase; Fructose-bisphosphate aldolase C\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 41\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799929278633,"sku":"81944T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-81944t","provider":"Iright","version":"1.0","type":"link"}