{"product_id":"cst-82196t","title":"CST,  82196T, JAM-A (E6Z7E) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying JAM-A. Validated for Western Blotting,Immunoprecipitation,Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, JAM-A (E6Z7E) Rabbit Monoclonal Antibody (CST #82196) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\nImmunofluorescence (Immunocytochemistry): 1:100 - 1:400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nJAM-A (E6Z7E) Rabbit Monoclonal Antibody recognizes endogenous levels of total JAM-A protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the central sequence of human JAM-A protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nJunctional Adhesion Molecule-A\/F11 Receptor (JAM-A\/F11R) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. JAM-A regulates multiple cellular processes, including tight junction assembly, epithelial-mesenchymal transition (EMT), leukocyte migration, virus binding, platelet activation, and angiogenesis. Â Aberrant expression of JAM-A is correlated with poor patient prognosis in several human cancers (1,2). In a mouse model of atherosclerosis, an antagonistic peptide that inhibits JAM-A-expressing platelets from interacting with inflamed endothelial cells reduces atherosclerotic plaque formation (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCD321; F11 receptor; F11R; JAM; JAM-1; JAM-A; JAM1; JAMA; JCAM; Junctional adhesion molecule 1; Junctional adhesion molecule A; KAT; PAM-1; Platelet adhesion molecule 1; Platelet F11 receptor\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 40\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799930458281,"sku":"82196T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-82196t","provider":"Iright","version":"1.0","type":"link"}