{"product_id":"cst-82536s","title":"CST,  82536S, GSTT1 (F6G2R) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying GSTT1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, GSTT1 (F6G2R) Rabbit Monoclonal Antibody (CST #82536) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nGSTT1 (F6G2R) Rabbit Monoclonal Antibody recognizes endogenous levels of total GSTT1 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val80 of human GSTT1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nGlutathione S-transferase theta-1 (GSTT1) is a member of the GST superfamily. Studies on mouse tumor models show that Gstt1 is not essential for primary tumor growth but is critical for tumor dissemination and metastasis. Gstt1 binds to intracellular fibronectin and modifies it by glutathionylation, increasing fibronectin secretion and deposition into the extracellular matrix (ECM) of the metastatic microenvironment. In addition, GSTT1, along with GSTM1, protects renal tubular cells from nephrotoxicity and ferroptosis induced by the chemotherapeutic agent cisplatin (2).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nglutathione S-transferase theta 1; Glutathione S-transferase theta-1; Glutathione transferase T1-1; GST class-theta-1; GSTT1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 23\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799933341865,"sku":"82536S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-82536s","provider":"Iright","version":"1.0","type":"link"}