{"product_id":"cst-82632s","title":"CST,  82632S, c-Maf (E2Q5D) Rabbit Monoclonal Antibody (PE Conjugate)","description":"Monoclonal Antibody for studying MAF. Validated for Flow Cytometry (Fixed\/Permeabilized). Highly specific and rigorously validated in-house, c-Maf (E2Q5D) Rabbit Monoclonal Antibody (PE Conjugate) (CST #82632) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nFlow Cytometry (Fixed\/Permeabilized): 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg\/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Flow Cytometry (Fixed\/Permeabilized)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nc-Maf (E2Q5D) Rabbit Monoclonal Antibody (PE Conjugate) recognizes endogenous levels of total c-Maf protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human c-Maf protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nTranscription factor c-Maf, also known as MAF and V-maf musculoaponeurotic fibrosarcoma oncogene homolog, is a basic leucine zipper transcription factor (bZIP) in the large Maf protein subclass and belongs to the AP-1 superfamily (1). In humans, there are three c-Maf isoforms and in mice, only two isoforms have been characterized (2). Maf proteins contain a highly conserved ancillary DNA binding domain, N-terminal to the basic domain, and bind to relatively long DNA sequences termed Maf-recognition elements (MAREs) (3). c-Maf can form homodimers and heterodimers with other bZIP proteins like Jun and Fos, as well as non-bZIP proteins (4,5). c-Maf plays an important role in lens fiber cell development, bone development, apoptosis, and the immune system (6,7). In T cells, c-Maf expression is induced by TCR stimulation, and sustained by co-stimulatory signals, and\/or cytokines like IL-4, IL-6, TGF-β, and IL-27 (8-12). In macrophages, c-Maf is required for self-renewal and promotes IL-10 production while inhibiting IL-12 (13,14). c-Maf plays a critical role in intestinal immune homeostasis, regulating ILC3s, Th17 cells, γδ T cells, and regulatory T (Treg) cells (7). c-Maf is an oncogene that contributes to the progression of some hematological malignancies and is expressed in other cancers but is not always correlated with poor prognosis (15,16).Â\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAvian musculoaponeurotic fibrosarcoma (MAF) protooncogene; AYGRP; c-MAF; c-maf proto-oncogene; CCA4; cMaf; CTRCT21; MAF; MAF bZIP transcription factor; MGC71685; Proto-oncogene c-Maf; T lymphocyte c-maf long form; Transcription factor Maf; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog; V-maf musculoaponeurotic fibrosarcoma oncogene homolog; v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800539812009,"sku":"82632S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-82632s","provider":"Iright","version":"1.0","type":"link"}