{"product_id":"cst-83017t","title":"CST,  83017T, hnRNP E2\/PCBP2 (D1S5E) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying hnRNP E2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, hnRNP E2\/PCBP2 (D1S5E) Rabbit Monoclonal Antibody (CST #83017) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nhnRNP E2\/PCBP2 (D1S5E) Rabbit Monoclonal Antibody recognizes endogenous levels of total hnRNP E2\/PCBP2 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu243 of human hnRNP E2\/PCBP2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPCBP2 (also known as hnRNP E2) is an RNA-binding protein that interacts in a sequence-specific fashion with single-stranded poly (rC). Through their poly(rC)-binding ability, PCBPs regulate mRNA stability and translation (1,2). PCBP2 is an iron chaperone; it delivers iron to ferritin for storage and mediates metalation of certain iron-containing proteins (3-5). PCBP2 interacts with the iron importer DMT1 (divalent metal transporter 1) and the iron exporter FPN1 (ferroportin 1) and regulates their activities (6,7). PCBP2 is induced by viral infection and targets MAVS for polyubiquitination and degradation (8-10). Recent reports demonstrate that it is involved in Hippo signaling, miRNA processing, immune suppression, and cancer (11-15) .\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAlpha-CP2; epididymis secretory sperm binding protein; Heterogeneous nuclear ribonucleoprotein E2; heterogenous nuclear ribonucleoprotein E2; hnRNP E2; hnRNP-E2; HNRNPE2; HNRPE2; MGC110998; PCBP2; poly(rC) binding protein 2; Poly(rC)-binding protein 2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 35-45\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799935013033,"sku":"83017T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-83017t","provider":"Iright","version":"1.0","type":"link"}