{"product_id":"cst-83267t","title":"CST,  83267T, Galectin-7\/LGALS7 (F9K7X) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Galectin-7. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Galectin-7\/LGALS7 (F9K7X) Rabbit Monoclonal Antibody (CST #83267) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nGalectin-7\/LGALS7 (F9K7X) Rabbit Monoclonal Antibody recognizes endogenous levels of total galectin-7\/LGALS7 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human galectin-7\/LGALS7 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nGalectin-7 belongs to the galectin family of carbohydrate-binding proteins, which specifically binds β-galactose-containing glycoconjugates and shares primary structural homology in the carbohydrate-recognition domain (CRD). Galectin-7 is a prototype galectin, containing a single CRD and forming homodimers (1). Galectin-7 is mainly expressed in stratified epithelial cells, where it contributes to tissue differentiation and development, and plays a crucial role in the re-epithelialization process of corneal or epidermal wounds induced by UV irradiation (2,3). The protein functions by stabilizing E-cadherin on the cell surface (4) and intracellularly activating JNK to induce pro-apoptotic caspase activity and cytochrome C release (5). Elevated galectin-7 expression is associated with many carcinomas. It promotes cancer migration and metastasis by activating ERK and JNK signaling, increasing MMP-9 and MMP-2 expression (6,7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nGal-7; GAL7; galectin 7B; Galectin-7; galectin-7B; HKL-14; keratinocyte lectin 14; lectin galactoside-binding soluble 7; lectin, galactoside-binding, soluble, 7B; LEG7; LGALS7; LGALS7B; MGC75149; MGC88745; p53-induced gene 1 protein; p53-induced protein 1; PI7; PIG1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 15\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799936520361,"sku":"83267T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-83267t","provider":"Iright","version":"1.0","type":"link"}