{"product_id":"cst-83525s","title":"CST,  83525S, POM121 Antibody","description":"Polyclonal Antibody for studying POM121. Validated for Western Blotting. Highly specific and rigorously validated in-house, POM121 Antibody (CST #83525) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPOM121 Antibody recognizes endogenous levels of total POM121 protein. This antibody detects all POM121 protein variants, including POM121A, POM121B, and POM121C.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human POM121 protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe nuclear pore complex (NPC) is a multi-subunit protein channel that spans the nuclear envelope and is responsible for the nucleocytoplasmic trafficking of RNA, proteins, and ribonucleoproteins (1,2). POM121, also referred to as nucleoporin Nup121, is a transmembrane nuclear protein that is an essential component of the NPC. POM121 expression is increased in aggressive, lethal prostate cancer and contributes to cancer progression and aggressiveness by enhancing the nuclear import of oncogenic transcription factors, such as E2F1, MYC, and GATA2, allowing for the upregulation of target genes (3). Elevated levels of POM121 have also been associated with poor outcome in patients with colorectal, lung, and laryngeal cancers, and it may serve as a prognostic biomarker for these cancer types (4-6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDKFZp586G1822; DKFZp586P2220; FLJ41820; KIAA0618; MGC3792; Nuclear envelope pore membrane protein POM 121; Nuclear envelope pore membrane protein POM 121A; nuclear pore membrane protein 121; nuclear pore membrane protein 121 kDa; Nucleoporin Nup121; NUP121; P121A; P145; POM121; POM121 membrane glycoprotein; POM121 membrane glycoprotein (rat); POM121 transmembrane nucleoporin; POM121A; Pore membrane protein of 121 kDa\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 150\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799938125993,"sku":"83525S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-83525s","provider":"Iright","version":"1.0","type":"link"}