{"product_id":"cst-83597s","title":"CST,  83597S, Resiquimod (R-848)","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nResiquimod (R-848) is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.06 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nResiquimod (R-848), an antiviral imidazoquinoline, has been shown to activate Toll-like receptor 7 (TLR7) and TLR8 via the MyD88-dependent interleukin 1 receptor (IL-1R)-TLR signaling pathway (1). Triggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genes (2). Similar to CD40, treatment with Resiquimod (R-848) activates B cells and can induce nuclear translocation of NF-κB at a concentration of 1 μg\/ml (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nR 848; R-848; R848; Resiquimod; S 28463; S28463","brand":"CST","offers":[{"title":"Default Title","offer_id":46800699162793,"sku":"83597S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-83597s","provider":"Iright","version":"1.0","type":"link"}