{"product_id":"cst-83775t","title":"CST,  83775T, CISD1\/mitoNEET (D5M4C) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ZCD1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, CISD1\/mitoNEET (D5M4C) Rabbit Monoclonal Antibody (CST #83775) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCISD1\/mitoNEET (D5M4C) Rabbit Monoclonal Antibody recognizes endogenous levels of total CISD1\/mitoNEET protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp61 of human CISD1\/mitoNEET protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCDGSH iron-sulfur domain-containing protein 1 (CISD1), also known as mitochondrial outer membrane iron-sulfur (2Fe-2S) protein (mitoNEET) was first identified as the target for the drug pioglitazone, used to treat diabetes (1-3). CISD1\/mitoNEET regulates both mitochondrial iron transport into the matrix and mitochondrial respiratory capacity. It has also been shown to affect the dynamics of cellular and whole-body lipid homeostasis (2,4). Furthermore, research studies have shown that CISD1\/mitoNEET is overexpressed in human epithelial breast cancer cells and it has been considered a potential chemotherapeutic target (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC10orf70; CDGSH iron sulfur domain 1; CDGSH iron sulfur domain-containing protein 1; CDGSH iron-sulfur domain-containing protein 1; CISD1; MDS029; MGC14684; MitoNEET; ZCD1; zinc finger CDGSH-type domain 1; zinc finger, CDGSH-type domain 1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 12\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799940026537,"sku":"83775T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-83775t","provider":"Iright","version":"1.0","type":"link"}