{"product_id":"cst-83805s","title":"CST,  83805S, ALDH1A2 Antibody","description":"Polyclonal Antibody for studying ALDH1A2. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, ALDH1A2 Antibody (CST #83805) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nALDH1A2 Antibody recognizes endogenous levels of total ALDH1A2 protein. Based on sequence comparisons, this antibody is not predicted to cross-react with ALDH1A1.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly350 of human ALDH1A2 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe aldehyde dehydrogenase family is a large group of enzymes that catalyze the oxidization of aldehydes into carboxylic acids (1). Aldehyde Dehydrogenase 1A2 (ALDH1A2, RALHD2) is among a group of aldehyde dehydrogenases that catalyze the metabolism of retinaldehyde into retinoic acid (RA), which plays a critically important signaling role in animal development (2). Research studies have shown that ALDH1A2 also plays a role postnatally in modulating the effects of RA signaling on immune cell function (3-5). In one example using a genetic mouse model, it was shown that ALDH1A2-dependent RA signaling was a downstream mediator of NOTCH-dependent T cell differentiation (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAL1A2; aldehyde dehydrogenase 1 family member A2; aldehyde dehydrogenase 1 family, member A2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; MGC26444; RALDH 2; RALDH(II); RALDH2; RALDH2-T; Retinal dehydrogenase 2; Retinaldehyde-specific dehydrogenase type 2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 55\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799939928233,"sku":"83805S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-83805s","provider":"Iright","version":"1.0","type":"link"}