{"product_id":"cst-83820t","title":"CST,  83820T, LAPTM5 (E7D5O) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying LAPTM5 mouse. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, LAPTM5 (E7D5O) Rabbit Monoclonal Antibody (CST #83820) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:500 - 1:2000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nLAPTM5 (E7D5O) Rabbit mAb recognizes endogenous levels of total LAPTM5 protein.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro246 of mouse LAPTM5 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nLysosomal-associated transmembrane protein 5 (LAPTM5) is a multi-pass transmembrane protein expressed in late endosomal\/lysosomal compartments of hematopoietic cells (1). LAPTM5 contains three PY motifs (L\/PPxY) and a ubiquitin-interacting motif (UIM). Transport of LAPTM5 to appropriate subcellular compartments requires LAPTM5 binding to the ubiquitin-ligase Nedd4 (2). Although the function of LAPTM5 remains unknown, it may function in immune cells to transport other molecules to be released from the lysosome once at the plasma membrane. Interestingly, the gene that encodes LAPTM5 was identified as an amyloid plaque-induced gene ( ) that is upregulated in microglia of mouse models of Alzheimer's disease (AD), suggesting that LAPTM5 may play a role in AD pathogenesis (3).Â\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nE3; LAPM5; Laptm5; Lysosomal-associated multitransmembrane protein 5; lysosomal-associated protein transmembrane 5; Lysosomal-associated transmembrane protein 5; OTTMUSP00000010034; Retinoic acid-inducible E3 protein; Stra13\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous\nMW (kDa): 15, 25\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800132800681,"sku":"83820T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-83820t","provider":"Iright","version":"1.0","type":"link"}