{"product_id":"cst-83912s","title":"CST,  83912S, LAMB1 (F1Q8V) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying LAMB1. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, LAMB1 (F1Q8V) Rabbit Monoclonal Antibody (CST #83912) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nLAMB1 (F1Q8V) Rabbit Monoclonal Antibody recognizes endogenous levels of total LAMB1 protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu1690 of human LAMB1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nLaminin Subunit Beta-1 (LAMB1) is a protein that is a part of the laminin family, which are extracellular matrix glycoproteins. Laminins are major components of basement membranes and play a critical role in cell adhesion, differentiation, migration, and phenotype stability. LAMB1 is involved in the assembly and stability of the basement membrane, which is a specialized sheet-like structure that surrounds muscle, fat, and nerve cells. It lines the surface of other cells, such as endothelial cells that line blood vessels (1). Mutations in the gene can lead to developmental abnormalities and diseases. For example, upregulation of LAMB1 promotes cell proliferation, invasion, and migration in gastric cancer (2). Furthermore, mutations are associated with cobblestone brain malformation, pain sensitivity, and blood-brain-barrier integrity (3-5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCLM; cutis laxa with marfanoid phenotype; LAMB1; Laminin B1 chain; laminin subunit beta 1; Laminin subunit beta-1; Laminin-1 subunit beta; Laminin-10 subunit beta; Laminin-12 subunit beta; Laminin-2 subunit beta; Laminin-6 subunit beta; Laminin-8 subunit beta; laminin, beta 1; LIS5; MGC142015\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 200\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799940124841,"sku":"83912S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-83912s","provider":"Iright","version":"1.0","type":"link"}