{"product_id":"cst-8428s","title":"CST,  8428S, Androgen Receptor (D6F11) Rabbit Monoclonal Antibody (PE Conjugate)","description":"Monoclonal Antibody for studying Androgen Receptor. Validated for Flow Cytometry (Fixed\/Permeabilized). Highly specific and rigorously validated in-house, Androgen Receptor (D6F11) Rabbit Monoclonal Antibody (PE Conjugate) (CST #8428) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nFlow Cytometry (Fixed\/Permeabilized): 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg\/ml BSA. Store at 4°C. Do not aliquot the antibodies. Protect from light. Do not freeze.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Flow Cytometry (Fixed\/Permeabilized)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nAndrogen Receptor (D6F11) Rabbit Monoclonal Antibody (PE Conjugate) detects endogenous levels of total androgen receptor protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a recombinant protein corresponding to residues near the amino terminal region of human androgen receptor protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nAndrogen receptor (AR), a zinc finger transcription factor belonging to the nuclear receptor superfamily, is activated by phosphorylation and dimerization upon ligand binding (1). This promotes nuclear localization and binding of AR to androgen response elements in androgen target genes. Research studies have shown that AR plays a crucial role in several stages of male development and the progression of prostate cancer (2,3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAIS; ANDR; Androgen receptor; AR; AR8; DHTR; Dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; TFM\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800542105769,"sku":"8428S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-8428s","provider":"Iright","version":"1.0","type":"link"}