{"product_id":"cst-8446s","title":"CST,  8446S, R-Ras Antibody","description":"Polyclonal Antibody for studying RRas. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, R-Ras Antibody (CST #8446) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nR-Ras Antibody recognizes endogenous levels of total R-Ras protein.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human R-Ras protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nR-Ras, a member of the small GTPase family, is homologous to H-, K- and N-Ras, but does not activate MAP kinase pathways and is only weakly oncogenic (1). Instead, R-Ras is engaged in integrin activation (2). The effector loop and the carboxy-terminal proline-rich and prenylation sites of R-Ras are critical for integrin activation (3,4). Phosphorylation by EphB2 receptor tyrosine kinase and Src at Tyr66 of R-Ras suppresses integrin activity (5,6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nOncogene RRAS; p23; R-Ras; ras family small GTP binding protein R-Ras; RAS related; Ras-related protein R-Ras; related RAS viral (r-ras) oncogene homolog; RRAS\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 24\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799943139497,"sku":"8446S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-8446s","provider":"Iright","version":"1.0","type":"link"}