{"product_id":"cst-84706s","title":"CST,  84706S, CHMP2A Antibody","description":"Polyclonal Antibody for studying CHMP2A. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, CHMP2A Antibody (CST #84706) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCHMP2A Antibody recognizes endogenous levels of total CHMP2A protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CHMP2A protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nCHMP2A is a component of ESCRT-III (endosomal sorting complex required for transport-III) (1,2). The ESCRT system is comprised of multiple protein complexes denoted as ESCRT-0, -I, -II, and -III, and VPS4 ATPase that are recruited to various cellular membranes and function fission reactions (3,4). Yeast contains four core ESCRT-III subunits: Vps20, Snf7, Vps24, and Vps2. Humans share these subunits and additionally have four Snf7 paralogs (CHMP4A-D) and two Vps2 paralogs (CHMP2A and B). The ESCRT-III complex comprising CHMP2A is involved in various membrane events, including multivesicular bodies, viral budding, cytokinesis, nuclear membrane reformation, and phagophore closure during autophagy and mitophagy (5-9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBC-2; BC2; Charged multivesicular body protein 2a; CHM2A; CHMP2; CHMP2A; chromatin modifying protein 2A; Chromatin-modifying protein 2a; hVps2-1; putative breast adenocarcinoma marker (32kD); Putative breast adenocarcinoma marker BC-2; Vacuolar protein sorting-associated protein 2-1; VPS2; VPS2 homolog A; Vps2-1; VPS2A\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 28, 31\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799945924777,"sku":"84706S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-84706s","provider":"Iright","version":"1.0","type":"link"}