{"product_id":"cst-84981t","title":"CST,  84981T, MAOB (D7O6X) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MAOB. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MAOB (D7O6X) Rabbit Monoclonal Antibody (CST #84981) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMAOB (D7O6X) Rabbit Monoclonal Antibody recognizes endogenous levels of total MAOB protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val51 of human MAOB protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMonoamine oxidase (MAO) enzymes are riboflavin proteins enriched in the outer membrane of the mitochondria that function to catalyze the oxidative deamination of tyramine and monoamine neurotransmitters (1). Monoamine neurotransmitters include dopamine, phenethylamine, 5-hydroxytryptamine, and norepinephrine. Two MAO isozymes are encoded in the mammalian genome, including MAOA and MAOB. Dopamine is a neurotransmitter in the brain that plays a key role in memory, movement, motivation, and mood. Dopamine dysregulation is also a key feature of neurodegenerative diseases, including Parkinson's disease (PD) (2). MAOs regulate dopamine abundance by metabolizing dopamine via presynaptic neurons (MAOA) or glial cells (MAOB). Inhibitors of MAOs are a potential therapeutic target to treat PD patients (3).Â\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nadrenalin oxidase; Amine oxidase [flavin-containing] B; AOFB; MAO-B; MAO, brain; MAO, platelet; MAOB; MGC26382; monoamine oxidase B; Monoamine oxidase type B; tyramine oxidase\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 62\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799947858089,"sku":"84981T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-84981t","provider":"Iright","version":"1.0","type":"link"}