{"product_id":"cst-8548t","title":"CST,  8548T, Phospho-IP3 Receptor (Ser1756) (D10E3) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying IP3R1 (Ser1764) phosphate. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Phospho-IP3 Receptor (Ser1756) (D10E3) Rabbit Monoclonal Antibody (CST #8548) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPhospho-IP3 Receptor (Ser1756) (D10E3) Rabbit Monoclonal Antibody detects endogenous levels of IP3 receptor only when phosphorylated at Ser1756.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser1764 of human IP3 receptor protein. This site is equivalent to Ser1756 in the rat IP3 receptor sequence.\n\u003cb\u003eBackground\u003c\/b\u003e\nInositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family and is located in the endoplasmic reticulum. IP3R functions as a Ca release channel for intracellular stores of calcium ions. There are three types of IP3 receptors (IP3R1, 2, and 3) that require the second messenger inositol 1,4,5-triphosphate (IP3) for activation (1). Four individual subunits homo- or hetero-oligomerize to form the receptor's functional channel (2). Phosphorylation of IP3R1 at Ser1756 by cyclic AMP-dependent protein kinase A (PKA) regulates the sensitivity of IP3R1 to IP3 and may be a mode of regulation for Ca release (3,4). IP3R1-mediated Ca release appears to have an effect on the induction of long term depression (LTD) in Purkinje cells (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nACV; CLA4; DKFZp313E1334; DKFZp313N1434; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor type 1; INSP3R1; IP3 receptor; IP3 receptor isoform 1; IP3R; IP3R 1; IP3R1; ITPR1; PPP1R94; protein phosphatase 1, regulatory subunit 94; SCA15; SCA16; SCA29; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 320\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799952609449,"sku":"8548T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-8548t","provider":"Iright","version":"1.0","type":"link"}