{"product_id":"cst-85786t","title":"CST,  85786T, Decorin (E2N2C) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Decorin. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, Decorin (E2N2C) Rabbit Monoclonal Antibody (CST #85786) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:100 - 1:400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 55868 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nDecorin (E2N2C) Rabbit Monoclonal Antibody recognizes endogenous levels of total decorin protein. This protein is heavily glycosylated, therefore, multiple bands or a smear may result from western blot analysis using this antibody.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro216 of human decorin protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nDecorin, named for its role in \"decorating\" type I collagen fibrils, is a collagen-binding proteoglycan that belongs to the small leucine-rich proteoglycan (SLRP) family (1). Through its binding to type I collagens and other important matrix proteins (e.g., fibronectin, thrombospondin, TGF-β), decorin plays a critically important role in assembly, maintenance, and physiological functions of the extracellular matrix. Notably, multiple research studies have reported anti-tumor functions for decorin and the related protein biglycan (2-4), implicating SLRP proteins as functionally important components of the tumor microenvironment (5). The anti-tumor effects of decorin have been ascribed to its interactions with cell surface receptors and associated signaling pathways (6), including those mediating inflammation, autophagy, and cell proliferation (7-9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBone proteoglycan II; CSCD; DCN; Decorin; decorin proteoglycan; dermatan sulphate proteoglycans II; DSPG2; PG-S2; PG40; PGII; PGS2; proteoglycan core protein; SLRR1B; small leucine-rich protein 1B\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 40, 100\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799955755177,"sku":"85786T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-85786t","provider":"Iright","version":"1.0","type":"link"}