{"product_id":"cst-85815s","title":"CST,  85815S, Bcl-xL (54H6) Rabbit Monoclonal Antibody (InTraSeq™ 3' Conjugate 3058)","description":"Monoclonal Antibody for studying BCL-xL. Validated for Single Cell Analysis - InTraSeq™ 3'. Highly specific and rigorously validated in-house, Bcl-xL (54H6) Rabbit Monoclonal Antibody (InTraSeq\u003csup\u003e™\u003c\/sup\u003e 3' Conjugate 3058) (CST #85815) is ready to ship.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in PBS (pH 7.2), 2 mM EDTA, 0.05% Triton X-100, 2 mg\/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Single Cell Analysis - InTraSeq™ 3'\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nBcl-xL (54H6) Rabbit Monoclonal Antibody (InTraSeq™ 3' Conjugate 3058) detects endogenous levels of total Bcl-xL protein. This antibody conjugate does not cross-react with other Bcl-2 family members.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp61 of human Bcl-xL.\n\u003cb\u003eBackground\u003c\/b\u003e\nBcl-xL prevents apoptosis through two different mechanisms: heterodimerization with an apoptotic protein inhibits its apoptotic effect (1,2) and formation of mitochondrial outer membrane pores help maintain a normal membrane state under stressful conditions (3). Bcl-xL is phosphorylated by JNK following treatment with microtubule-damaging agents, such as paclitaxel, vinblastine, and nocodazole (4,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nApoptosis regulator Bcl-X; B2CL1; Bcl-2-like protein 1; Bcl-X; bcl-xL; BCL-XL\/S; bcl-xS; BCL2 like 1; Bcl2-L-1; BCL2-like 1; BCL2L; BCL2L1; BCLX; BCLXL; BCLXS; DKFZp781P2092; PPP1R52; protein phosphatase 1, regulatory subunit 52\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800779804841,"sku":"85815S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-85815s","provider":"Iright","version":"1.0","type":"link"}