{"product_id":"cst-86425s","title":"CST,  86425S, RBM5 (E8G8K) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying RBM5. Validated for Western Blotting,Immunoprecipitation,eCLIP. Available in 2 sizes. Highly specific and rigorously validated in-house, RBM5 (E8G8K) Rabbit Monoclonal Antibody (CST #86425) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nFor more information about the RBP-eCLIP service please visit Eclipsebio .\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\neCLIP: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nRBM5 (E8G8K) Rabbit Monoclonal Antibody recognizes endogenous levels of total RBM5 protein.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly325 of human RBM5 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nRBM5 is an RNA binding protein that regulates alternative splicing through association with the spliceosome (1,2). First identified as a tumor suppressor gene, RBM5 interacts with U2AF65 in order to regulate many pro-apoptotic genes, such as Fas (3). RBM5 is notably deleted in many lung cancers, and also has been shown to be a key regulator in male germ cell pre-mRNA splicing (4-6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFLJ39876; G15; H37; LUCA-15; LUCA15; Protein G15; Putative tumor suppressor LUCA15; RBM5; Renal carcinoma antigen NY-REN-9; RMB5; RNA binding motif protein 5; RNA-binding motif protein 5; RNA-binding protein 5\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 130\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799960965289,"sku":"86425S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-86425s","provider":"Iright","version":"1.0","type":"link"}