{"product_id":"cst-86428s","title":"CST,  86428S, MCC-950 (sodium salt)","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nMCC-950 (sodium salt) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.17 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nMCC-950 (sodium salt), also known as CRID3, is a potent and selective NOD-like receptor (NLR) family pyrin domain-containing protein 3 (NLRP3) inhibitor. NLRP3 is an inflammasome-forming NLR that activates caspase-1, leading to maturation of IL-1β and IL-18 (1). MCC-950 (sodium salt) inhibits IL-1β production in mouse bone marrow-derived macrophage (BMDM) cells with an IC value of 7.5 nM (2). The NLRP3 inflammasome is involved in different diseases such as Parkinson's disease (PD), multiple sclerosis (MS), type 2 diabetes, and atherosclerosis, making MCC-950 (sodium salt) an important compound when studying different autoinflammatory and autoimmune diseases (2,3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCP-456773 sodium salt; CRID3; CRID3 sodium salt; Cytokine release inhibitory drug 3; MCC-950; MCC950; N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2- furansulfonamide sodium salt","brand":"CST","offers":[{"title":"Default Title","offer_id":46800699424937,"sku":"86428S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-86428s","provider":"Iright","version":"1.0","type":"link"}