{"product_id":"cst-86622s","title":"CST,  86622S, LRBA Antibody","description":"Polyclonal Antibody for studying LRBA. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, LRBA Antibody (CST #86622) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nLRBA Antibody recognizes endogenous levels of total LRBA protein. This antibody detects a 130 kDa band of unknown origin in some cell lines.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human LRBA protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nLRBA (lipopolysaccharide responsive beige-like anchor protein) is a 300 kDa intracellular protein that is a member of the PH-BEACH-WD40 protein family (1-3). Its BEACH domain contains an A-kinase anchoring protein (AKAP) motif, known to have an affinity for signaling enzymes (1,3). LRBA has been found to be overexpressed in several different cancers, such as renal, pancreas, colorectal, and lung (2). LRBA deficiency, caused by various mutations, can cause common variable immune deficiency (CVID) as well as other immune dysregulations (3,5). LRBA plays an immunoregulatory role to CTLA-4, protecting it from being degraded within lysosomes (4,6). In LRBA deficiency, CTLA-4 is synthesized normally, but is not delivered to Rab GTPase recycling compartments, instead resulting in enhanced lysosome degradation (4,6,7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBeige-like protein; BGL; CDC4-like protein; CDC4L; cell division cycle 4-like; CVID8; DKFZp686A09128; DKFZp686K03100; DKFZp686P2258; FLJ16600; FLJ25686; LAB300; LBA; Lipopolysaccharide-responsive and beige-like anchor protein; LPS responsive beige-like anchor protein; LPS-responsive vesicle trafficking, beach and anchor containing; LRBA; MGC72098; vesicle trafficking, beach and anchor containing\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 320\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799962636457,"sku":"86622S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-86622s","provider":"Iright","version":"1.0","type":"link"}