{"product_id":"cst-86955s","title":"CST,  86955S, GLIPR2 (F7H7V) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying GLIPR2. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, GLIPR2 (F7H7V) Rabbit Monoclonal Antibody (CST #86955) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:100 - 1:400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nGLIPR2 (F7H7V) Rabbit Monoclonal Antibody recognizes endogenous levels of total GLIPR2 protein. An unknown background band is detected at 65 kDa in some human and mouse cell lines.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro135 of human GLIPR2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nGlioma pathogenesis-related protein 2 (GLIPR2), also known as Golgi-associated PR-1 protein (GAPR-1), is a Golgi-associated protein belonging to the PR-1 protein family (1). GLIPR2 contains a sperm-coating protein (SCP) domain, also known as a CAP domain; however, in contrast to other SCP domain-containing proteins, it does not have a signal peptide and is not secreted via the classical secretory pathway (2). GLIPR2 is expressed in monocytes, macrophages, natural killer (NK) cells, and T cell subsets (3). GLIPR2 binds Beclin-1 and is a negative regulator of autophagy that inhibits PtdIns3K-C1 complex activity (4,5). GLIPR2 promotes epithelial to mesenchymal transition , and is expressed at high levels in fibrotic kidney (6). GLIPR2 has been identified as a marker for type 1 migratory dendritic cells (DC1s) (7) and a potential biomarker and tumor suppressor in a pan-cancer analysis (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n17kD fetal brain protein; C9orf19; GAPR-1; GAPR1; GLI pathogenesis related 2; GLI pathogenesis-related 2; Glioma pathogenesis-related protein 2; GliPR 2; GLIPR2; Golgi-associated plant pathogenesis-related protein 1; Golgi-associated PR-1 protein\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 17\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799965585577,"sku":"86955S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-86955s","provider":"Iright","version":"1.0","type":"link"}