{"product_id":"cst-8705s","title":"CST,  8705S, Sorafenib","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nSorafenib is supplied as a lyophilized powder. For a 10 mM stock, reconstitute the 10 mg in 1.57 ml DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used as a pretreatment at 0.1-10 µM for 0.5-2 hr prior to treating with a stimulator. It can also be used alone, with varying treatment times lasting up to 24 hr. Soluble in DMSO at 200 mg\/ml; very poorly soluble in ethanol and water with maximum solubility in water ~10-20 µM.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized or in solution at -20ºC. In lyophlized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency.\n\u003cb\u003eBackground\u003c\/b\u003e\nSorafenib, also known as Bay 43-9006, is a novel multikinase inhibitor that targets the RAF family of serine\/threonine kinases and tyrosine kinase receptors involved in tumor progression and tumor angiogenesis, including: VEGFR-2 (IC = 90 nM), VEGFR-3 (IC = 20 nM), PDGFR- (IC = 57 nM), c-KIT (IC = 68 nM), and Flt3 (IC = 58 nM) (1). Research studies have demonstrated that sorafenib induces apoptosis in several tumor cell lines through the down-regulation of the antiapoptotic protein myeloid cell leukemia-1 (Mcl-1). Down-regulation of Mcl-1 by sorafenib is associated with the release of cytochrome c from mitochondria into the cytosol and caspase activation, leading to apoptotic cell death (2). STAT3 inhibition by sorafenib has been observed in multiple cell types (3-5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nangiogenesis; apoptosis; Bay 43-9006; c-KIT; Flt3; Mcl-1; PDGFR-; RAF; STAT3; VEGFR-2; VEGFR-3","brand":"CST","offers":[{"title":"Default Title","offer_id":46800699556009,"sku":"8705S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-8705s","provider":"Iright","version":"1.0","type":"link"}