{"product_id":"cst-87189t","title":"CST,  87189T, OXR1 (E3D2P) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying OXR1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, OXR1 (E3D2P) Rabbit Monoclonal Antibody (CST #87189) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nOXR1 (E3D2P) Rabbit Monoclonal Antibody recognizes endogenous levels of total OXR1 protein. Based on the sequence of the antigenic peptide, this antibody is expected to detect isoforms 1, 2, 3, 5, and 8 of OXR1.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val180 of human OXR1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nOxidation resistance 1 (OXR1) protein is a cellular oxidative stress sensor that regulates expression of signaling proteins involved in cell cycle arrest and apoptosis (1). Depletion of OXR1 plays a role in oxidative stress associated with neurodegenerative diseases, including Parkinson's disease, diabetic retinopathy, hyperoxia induced retinopathy, and neuronal damage (2). OXR1 also plays a role in cell cycle arrest in response to DNA damage (3,4), and is upregulated in cells undergoing senescence (5). OXR1 is a target of the senolytic agent, piperlongumine, and its analogues (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCHEGDD; FLJ10125; FLJ38829; FLJ41673; FLJ42450; FLJ45656; Nbla00307; oxidation resistance 1; Oxidation resistance protein 1; OXR1; putative protein product of Nbla00307; TBC\/LysM-associated domain containing 3; TLDC3\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 139\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799968207017,"sku":"87189T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-87189t","provider":"Iright","version":"1.0","type":"link"}