{"product_id":"cst-87214s","title":"CST,  87214S, NCR3\/NKp30 (F3O3Q) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying NCR3. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, NCR3\/NKp30 (F3O3Q) Rabbit Monoclonal Antibody (CST #87214) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nNCR3\/NKp30 (F3O3Q) Rabbit Monoclonal Antibody recognizes endogenous levels of total NCR3\/NKp30 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu86 of human NCR3\/NKp30 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe family of natural cytotoxicity receptors (NCRs) contains NCR1 (NKp46\/CD335), NCR2 (NKp44\/CD336), and NCR3 (NKp30\/CD337). They are single-pass type I transmembrane proteins belonging to the immunoglobulin (Ig) superfamily. Various pathogen-derived and host-encoded molecules have been identified as ligands for the NCRs. They were originally identified by their ability to evoke the cytotoxicity of natural killer (NK) cells toward tumor cells , and animal models have demonstrated that NCRs play a role in tumor surveillance, viral infection, and pregnancy (1-5). NCR3\/NKp30 is constitutively expressed in NK cells and at low levels in subpopulations of CD8 cytotoxic T lymphocytes and γδ T cells (6, 7). NCR3\/NKp30 is being investigated as a target for immunotherapies due to its role in mediating NK cell antitumor effects (8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n1C7; Activating natural killer receptor p30; activating NK-A1 receptor; CD337; LY117; lymphocyte antigen 117; MALS; Natural cytotoxicity triggering receptor 3; Natural killer cell p30-related protein; NCR3; NCTR3; NK-p30; NKp30\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 25-50\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799968469161,"sku":"87214S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-87214s","provider":"Iright","version":"1.0","type":"link"}