{"product_id":"cst-87416s","title":"CST,  87416S, CRELD1 (E1B6T) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CRELD1. Validated for Western Blotting,Immunoprecipitation,Flow Cytometry (Live). Available in 2 sizes. Highly specific and rigorously validated in-house, CRELD1 (E1B6T) Rabbit Monoclonal Antibody (CST #87416) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\nFlow Cytometry (Live): 1:50 - 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Flow Cytometry (Live)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCRELD1 (E1B6T) Rabbit Monoclonal Antibody recognizes endogenous levels of total CRELD1 protein. Species reactivity for flow cytometry is human only.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CRELD1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCysteine-rich with EGF-like domain protein 1 (CRELD1), also known as cirrin, is a multi-pass membrane protein in the CRELD family of ER-resident proteins (1-3). During embryonic development, CRELD1 is critical to heart development, and mutations in are associated with atrioventricular septal defect 2 (AVSD2), a common cardiovascular malformation (2-4). CRELD1 may also play a role in homeostasis of the immune system, as low CRELD1 expression was found to be associated with reduced T cell numbers in blood (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAVSD2; CIRRIN; CREL1; CRELD1; cysteine rich with EGF like domains 1; Cysteine-rich with EGF-like domain protein 1; cysteine-rich with EGF-like domains 1; DKFZp566D213; Protein disulfide isomerase CRELD1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 45\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799969845417,"sku":"87416S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-87416s","provider":"Iright","version":"1.0","type":"link"}