{"product_id":"cst-87548s","title":"CST,  87548S, Mouse FGF-basic\/FGF2 Recombinant Protein","description":"Growth Factors and Cytokines for studying FGF2 mouse in the research area.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nMouse FGF-basic\/FGF2 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg\/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles if storing reconstituted material at -20ºC to -80ºC.\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nRecombinant mouse FGF-basic was expressed in and is supplied in a lyophilized form.\n\u003cb\u003eBackground\u003c\/b\u003e\nFGF-basic (FGF2) is produced in both embryonic and adult cell types, and contributes to the pathogenesis of various diseases, including cancer and atherosclerosis (1). FGF-basic is involved in developmental processes and regulates differentiation, proliferation, and migration (1-6). FGF-basic is a critical factor for growing embryonic stem cells in culture without inducing differentiation. FGF-basic has a high affinity for heparan sulfate (1,2) and binding is a step in the FGF-basic activation of FGFR tyrosine kinase. There are four distinct FGF receptors and each has multiple splice variants. FGF-basic binds with high affinity to many, but not all, FGFRs. Signaling cascades activated through FGF-basic binding to FGFR include the ras-raf-MAPK, PLCγ\/PKC, and PI3K\/Akt pathways (1).","brand":"CST","offers":[{"title":"Default Title","offer_id":46800717611177,"sku":"87548S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-87548s","provider":"Iright","version":"1.0","type":"link"}