{"product_id":"cst-88183t","title":"CST,  88183T, TNFRSF17\/BCMA (E6D7B) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TNFRSF17. Validated for WB,IP,IHC,IHC,F. Available in 2 sizes. Highly specific and rigorously validated in-house, TNFRSF17\/BCMA (E6D7B) Rabbit Monoclonal Antibody (CST #88183) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:8000\nImmunoprecipitation: 1:800\nIHC Leica Bond: 1:150 - 1:600\nImmunohistochemistry (Paraffin): 1:300 - 1:1200\nFlow Cytometry (Fixed\/Permeabilized): 1:1600 - 1:6400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier-free (BSA and azide free) version of this product see product # 84031 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, IHC Leica Bond, Immunohistochemistry (Paraffin), Flow Cytometry (Fixed\/Permeabilized)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTNFRSF17\/BCMA (E6D7B) Rabbit Monoclonal Antibody recognizes endogenous levels of total TNFRSF17\/BCMA protein. This antibody displays some non-specific staining of peripheral and CNS tissue when used for IHC-P.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu115 of human TNFRSF17\/BCMA protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nB cell maturation antigen (BCMA\/TNFRSF17\/CD269) is a transmembrane glycoprotein and member of the TNFR superfamily (1). BCMA expression is largely restricted to the B cell lineage. Pro-survival signaling through this receptor plays a pivotal role in humoral immunity by regulating B cell maturation and plasma cell differentiation upon binding its ligands, BAFF and APRIL (2-6). BCMA is expressed in a number of B cell malignancies and has garnered much attention as a novel therapeutic target for the treatment of multiple myeloma due to its selective and elevated expression on the cell surface of malignant plasma cells (7-10).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nB cell maturation antigen; B-cell maturation factor; B-cell maturation protein; BCM; BCMA; CD269; TNF receptor superfamily member 17; TNFRSF13A; TNFRSF17; TNR17; Tumor necrosis factor receptor superfamily member 17; tumor necrosis factor receptor superfamily, member 17\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 18-30\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799978856617,"sku":"88183T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-88183t","provider":"Iright","version":"1.0","type":"link"}